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0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F3 1 Tf
10 0 0 10 207.5032 314.3617 Tm
0 0 0 1 k
/GS1 gs
0 Tc
0 Tw
(.)Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F4 1 Tf
10 0 0 10 37 297.3617 Tm
0 0 0 1 k
/GS1 gs
-0.0001 Tc
0 Tw
(Animals )Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F1 1 Tf
10 0 0 10 37 283.4617 Tm
0 0 0 1 k
/GS1 gs
-0.0201 Tc
0 Tw
(Male )Tj
0 g
2.1997 0 TD
0 Tc
(W)Tj
0.884 0 TD
-0.0201 Tc
0.025 Tw
[(istar rats, 8 to 9 w)34.8(eeks of age and)]TJ
-3.0837 -1.19 TD
0 Tc
0 Tw
(w)Tj
0.667 0 TD
-0.02 Tc
0.0249 Tw
[(eighing 180 to 200 g, w)34.9(ere obtained from)]TJ
-0.667 -1.19 TD
[(the Experimental )54.8(Animal House Center)39.7(,)]TJ
T*
0 Tc
0 Tw
(F)Tj
0.4761 0 TD
-0.0201 Tc
0.025 Tw
[(aculty of Medicine, King Saud Uni)24.7(v)14.8(ersity)84.9(,)]TJ
-0.4761 -1.19 TD
[(Riyadh, Saudi )54.8(Arabia. )54.8(All animals w)34.8(ere gi)24.8(v)14.8(e)0(n)]TJ
T*
[(food \(rat cho)39.7(w or date e)14.8(xtract\) and w)24.8(ater ad)]TJ
T*
[(libitum, and w)34.8(ere maintained at a relati)24.7(v)14.8(e)]TJ
T*
(humidity of 65% to 86%, a temperature of)Tj
T*
[(23C to 25C, and in a schedule of 12 hours)]TJ
T*
(of light and 12 hours of dark \(lights on at)Tj
T*
[(0600\). Rats w)34.8(ere w)34.8(eighed at the be)14.8(ginning)]TJ
T*
[(and end of the study)84.8(. Procedures in)39.7(v)19.7(olving)]TJ
T*
[(animals and their care w)34.8(ere conducted in con-)]TJ
T*
[(for)-19.9(mity with inter)-19.9(national la)39.7(ws and policies.)]TJ
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F4 1 Tf
10 0 0 10 37 111.7618 Tm
0 0 0 1 k
/GS1 gs
-0.0001 Tc
0 Tw
(Chemicals)Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F1 1 Tf
10 0 0 10 37 97.8618 Tm
0 0 0 1 k
/GS1 gs
-0.0051 Tc
0 Tw
(High-g)Tj
0 g
2.8223 0 TD
0.025 Tw
[(rade chemicals w)34.8(ere obtained from)]TJ
-2.8223 -1.19 TD
(Sigma-Aldrich and included CCl)Tj
6 0 0 6 168.1649 83.9819 Tm
0 Tc
0 Tw
(4)Tj
10 0 0 10 171.1349 85.9619 Tm
-0.0051 Tc
0.025 Tw
[(, ether)39.7(,)]TJ
-13.4135 -1.19 TD
[(absolute ethanol, xylol, meth)29.6(yl benzoate,)]TJ
T*
[(hemato)19.7(xylin, eosin red)59.7(, paraf)24.8(f)-59.7(in \(melting)]TJ
T*
[(point, 60C70C\), and bees)19.6(w)24.9(ax.)]TJ
ET
1 g
234 639 180 -594.002 re
f
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F4 1 Tf
10 0 0 10 235 631.2324 Tm
0 0 0 1 k
/GS1 gs
-0.0001 Tc
0.025 Tw
(Assessment of Hepatopr)Tj
0 g
10.3498 0 TD
-0.0002 Tc
-0.0598 Tw
[(otecti)9.6(v)29.6(e)-0.1( Acti)9.6(vity)]TJ
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F1 1 Tf
10 0 0 10 250 617.7324 Tm
0 0 0 1 k
/GS1 gs
-0.0051 Tc
0.025 Tw
(Sixty animals w)Tj
0 g
6.3837 0 TD
[(ere randoml)24.8(y di)24.8(vided)]TJ
-7.8837 -1.2 TD
[(equall)24.8(y into six g)-19.9(roups of 10:)]TJ
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F4 1 Tf
10 0 0 10 235 589.2324 Tm
0 0 0 1 k
/GS1 gs
-0.0253 Tc
0 Tw
(Gr)Tj
0 g
1.1419 0 TD
-0.025 Tc
0.025 Tw
(oup 1 )Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F1 1 Tf
10 0 0 10 271.5376 589.2324 Tm
0 0 0 1 k
/GS1 gs
-0.0251 Tc
0.025 Tw
(\(controls\): recei)Tj
0 g
5.9319 0 TD
[(ving nor)-19.8(mal saline)]TJ
-9.5856 -1.2 TD
[(orall)24.8(y \(0.2 ml/100 g\) for 16 consecuti)24.9(v)14.8(e)0( da)34.8(ys.)]TJ
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F4 1 Tf
10 0 0 10 235 562.2324 Tm
0 0 0 1 k
/GS1 gs
-0.0053 Tc
0 Tw
(Gr)Tj
0 g
1.1819 0 TD
-0.005 Tc
0.025 Tw
(oup 2)Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F1 1 Tf
10 0 0 10 273.1374 562.2324 Tm
0 0 0 1 k
/GS1 gs
-0.0052 Tc
0.0251 Tw
[(\(pretreatment e)]TJ
0 g
6.014 0 TD
0 Tw
(xperiment-)Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F3 1 Tf
10 0 0 10 376.6449 562.2324 Tm
0 0 0 1 k
/GS1 gs
-0.0051 Tc
0 Tw
(flesh)Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F1 1 Tf
10 0 0 10 395.2793 562.2324 Tm
0 0 0 1 k
/GS1 gs
-0.0054 Tc
0 Tw
(\):)Tj
0 g
-16.0279 -1.2 TD
-0.0051 Tc
0.025 Tw
[(allo)39.7(w)34.9(ed free access to aqueous e)14.7(xtract of)]TJ
T*
[(date flesh ad libitum for 28 consecuti)24.7(v)14.8(e)0( da)34.8(ys)]TJ
T*
(and treated with intraperitoneal \(IP\) CCl)Tj
6 0 0 6 396.0762 524.2524 Tm
-0.005 Tc
0 Tw
(4 )Tj
10 0 0 10 400.6662 526.2324 Tm
(on)Tj
-16.5666 -1.2 TD
-0.0051 Tc
0.025 Tw
[(Da)34.8(ys 14, 15, and 16 of the treatment period.)]TJ
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F4 1 Tf
10 0 0 10 235 499.2325 Tm
0 0 0 1 k
/GS1 gs
-0.0053 Tc
0 Tw
(Gr)Tj
0 g
1.1819 0 TD
-0.005 Tc
0.025 Tw
(oup 3)Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F1 1 Tf
10 0 0 10 273.1374 499.2325 Tm
0 0 0 1 k
/GS1 gs
-0.0051 Tc
0.025 Tw
(\(post-treatment e)Tj
0 g
6.7269 0 TD
0 Tw
(xperiment-)Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F3 1 Tf
10 0 0 10 383.774 499.2325 Tm
0 0 0 1 k
/GS1 gs
-0.0051 Tc
0 Tw
(flesh)Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F1 1 Tf
10 0 0 10 402.4084 499.2325 Tm
0 0 0 1 k
/GS1 gs
-0.0054 Tc
0 Tw
(\):)Tj
0 g
-16.7408 -1.2 TD
-0.0051 Tc
0.025 Tw
[(gi)24.8(v)14.8(en aqueous e)14.8(xtract of date flesh ad libi-)]TJ
T*
[(tum for 14 consecuti)24.8(v)14.8(e)0( da)34.8(ys and treated)]TJ
T*
(with IP CCl)Tj
6 0 0 6 282.7311 461.2524 Tm
0 Tc
0 Tw
(4)Tj
10 0 0 10 288.4011 463.2325 Tm
-0.005 Tc
0.025 Tw
[(on Da)34.9(ys 1, 2, and 3 of the)]TJ
-5.3401 -1.2 TD
-0.0051 Tc
(treatment period. )Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F4 1 Tf
10 0 0 10 235 436.2325 Tm
0 0 0 1 k
/GS1 gs
-0.0053 Tc
0 Tw
(Gr)Tj
0 g
1.1819 0 TD
-0.005 Tc
0.025 Tw
(oup 4)Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F1 1 Tf
10 0 0 10 273.1374 436.2325 Tm
0 0 0 1 k
/GS1 gs
-0.0052 Tc
0.0251 Tw
[(\(pretreatment e)]TJ
0 g
6.014 0 TD
0 Tw
(xperiment-)Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F3 1 Tf
10 0 0 10 376.6449 436.2325 Tm
0 0 0 1 k
/GS1 gs
-0.0051 Tc
0 Tw
(pits)Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F1 1 Tf
10 0 0 10 390.8908 436.2325 Tm
0 0 0 1 k
/GS1 gs
-0.0054 Tc
0 Tw
(\):)Tj
0 g
-15.5891 -1.2 TD
-0.0051 Tc
0.025 Tw
[(allo)39.7(w)34.9(ed aqueous e)14.8(xtract of date pits ad libi-)]TJ
T*
[(tum for 28 consecuti)24.8(v)14.8(e)0( da)34.8(ys and treated)]TJ
T*
(with IP CCl)Tj
6 0 0 6 282.7311 398.2525 Tm
-0.005 Tc
0 Tw
(4 )Tj
10 0 0 10 287.3211 400.2324 Tm
0.025 Tw
[(on Da)34.9(ys 14, 15, and 16 of the)]TJ
-5.2321 -1.2 TD
-0.0051 Tc
(treatment period. )Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F4 1 Tf
10 0 0 10 235 373.2324 Tm
0 0 0 1 k
/GS1 gs
-0.0053 Tc
0 Tw
(Gr)Tj
0 g
1.1819 0 TD
-0.005 Tc
0.025 Tw
(oup 5)Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F1 1 Tf
10 0 0 10 273.1374 373.2324 Tm
0 0 0 1 k
/GS1 gs
-0.0051 Tc
0.025 Tw
(\(post-treatment e)Tj
0 g
6.7269 0 TD
0 Tw
(xperiment-)Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F3 1 Tf
10 0 0 10 383.774 373.2324 Tm
0 0 0 1 k
/GS1 gs
-0.0051 Tc
0 Tw
(pits)Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F1 1 Tf
10 0 0 10 398.0199 373.2324 Tm
0 0 0 1 k
/GS1 gs
-0.0054 Tc
0 Tw
(\):)Tj
0 g
-16.302 -1.2 TD
-0.0051 Tc
0.025 Tw
[(gi)24.8(v)14.8(en aqueous e)14.8(xtract of date pits ad libitum)]TJ
T*
[(for 14 consecuti)24.8(v)14.8(e)0( da)34.8(ys and treated with IP)]TJ
T*
0 Tw
(CCl)Tj
6 0 0 6 250.9682 335.2525 Tm
0 Tc
(4)Tj
10 0 0 10 256.6383 337.2324 Tm
-0.0051 Tc
0.025 Tw
[(on Da)34.8(ys 1, 2, and 3 of the treatment)]TJ
-2.1638 -1.2 TD
0 Tw
(period. )Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F4 1 Tf
10 0 0 10 235 310.2324 Tm
0 0 0 1 k
/GS1 gs
-0.0053 Tc
0 Tw
(Gr)Tj
0 g
1.1819 0 TD
-0.005 Tc
0.025 Tw
(oup 6)Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F1 1 Tf
10 0 0 10 273.1374 310.2324 Tm
0 0 0 1 k
/GS1 gs
-0.0051 Tc
0 Tw
(\(CCl)Tj
6 0 0 6 292.3833 308.2525 Tm
0 g
0 Tc
(4)Tj
10 0 0 10 295.3533 310.2324 Tm
-0.0051 Tc
0.025 Tw
(-treated control\): injected)Tj
-6.0353 -1.2 TD
[(with a fresh mixture of equal v)19.6(olumes of)]TJ
T*
0 Tw
(CCl)Tj
6 0 0 6 250.9682 284.2524 Tm
0 Tc
(4)Tj
10 0 0 10 256.6383 286.2324 Tm
-0.0051 Tc
0.025 Tw
[(and oli)24.8(v)14.8(e)0( oil b)24.8(y)0( three IP injections at)]TJ
-2.1638 -1.2 TD
-0.005 Tc
[(doses of 0.2 ml/100 g body w)34.9(eight.)]TJ
0 -2.1 TD
-0.125 Tc
0 Tw
(Tw)Tj
1.168 0 TD
-0.0051 Tc
0.025 Tw
(enty-four hours after the last treatment)Tj
-1.168 -1.2 TD
-0.0101 Tc
[(\(Da)34.8(y 16 or Da)34.9(y 29\) the rats w)34.9(ere euthanized.)]TJ
T*
-0.0051 Tc
[(Hepatoprotecti)24.8(v)14.8(e)0.1( acti)24.8(vity w)24.8(as calculated)]TJ
T*
[(according to the for)-19.9(mula of Singh et al:)]TJ
5 0 0 5 392.3928 220.7012 Tm
0 Tc
0 Tw
(7)Tj
10 0 0 10 261.2154 198.7324 Tm
-0.0051 Tc
0.025 Tw
[(Hepatoprotecti)24.8(v)14.8(e)0.1( acti)24.8(vity \(%\) =)]TJ
2.583 -1.9 TD
-0.005 Tc
(1 )Tj
1.53 0.7 TD
-0.0051 Tc
(\(PC - S\) )Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F8 1 Tf
10 0 0 10 337.9165 179.7325 Tm
0 0 0 1 k
/GS1 gs
0 Tc
0 Tw
()Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F1 1 Tf
10 0 0 10 346.0549 179.7325 Tm
0 0 0 1 k
/GS1 gs
-0.005 Tc
0 Tw
(100)Tj
0 g
-4.0854 -0.65 TD
-0.0051 Tc
0.025 Tw
(\(C - S\))Tj
-7.0201 -1.9 TD
0 Tc
0 Tw
(w)Tj
0.6972 0 TD
-0.0051 Tc
0.025 Tw
[(here PC, C, and S are the measurab)19.6(le v)24.8(ari-)]TJ
-0.6972 -1.2 TD
[(ab)19.7(les in rats treated with date flesh or pits)]TJ
T*
(plus CCl)Tj
6 0 0 6 270.1359 128.2524 Tm
0 Tc
0 Tw
(4)Tj
10 0 0 10 273.1059 130.2325 Tm
-0.0051 Tc
0.0251 Tw
(, CCl)Tj
6 0 0 6 294.2242 128.2524 Tm
-0.005 Tc
0 Tw
(4,)Tj
10 0 0 10 301.3643 130.2325 Tm
-0.0051 Tc
0.025 Tw
(and saline-treated animals,)Tj
-6.6364 -1.2 TD
0 Tw
[(respecti)24.7(v)14.7(el)24.7(y)84.8(.)]TJ
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F4 1 Tf
10 0 0 10 235 101.2324 Tm
0 0 0 1 k
/GS1 gs
-0.0001 Tc
0.025 Tw
(Blood Sampling )Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F1 1 Tf
10 0 0 10 235 87.2325 Tm
0 0 0 1 k
/GS1 gs
-0.005 Tc
0.025 Tw
(Blood w)Tj
0 g
3.3819 0 TD
-0.0051 Tc
(as collected in heparinized tubes)Tj
-3.3819 -1.2 TD
(from the inner canthus on the 29)Tj
5 0 0 5 364.857 78.7012 Tm
0 Tw
(th)Tj
10 0 0 10 371.3962 75.2325 Tm
0.025 Tw
[(da)34.8(y or the)]TJ
-13.6396 -1.2 TD
-0.005 Tc
0 Tw
(16)Tj
5 0 0 5 244.9001 66.7012 Tm
-0.0052 Tc
(th)Tj
10 0 0 10 251.4393 63.2325 Tm
0.025 Tw
[(da)34.8(y in the pre- or post-treated g)-19.9(roups,)]TJ
-1.6439 -1.2 TD
[(respecti)24.8(v)14.8(el)24.8(y)84.9(.)0( Plasma w)24.8(as separated b)24.8(y)0( cen-)]TJ
ET
0 G
0 J 0 j 0.5 w 10 M []0 d
302.5 182.5 m
333.5 182.5 l
S
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F6 1 Tf
11.5 0 0 11.5 393.8719 26.4631 Tm
0 0 0 1 k
/GS1 gs
-0.0001 Tc
0 Tw
(177)Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F3 1 Tf
9.5 0 0 9.5 37 26.7505 Tm
0 0 0 1 k
/GS1 gs
-0.0001 Tc
0.025 Tw
(Intern J )Tj
0 g
3.3774 0 TD
0 Tc
[(Appl Res )74.9(V)140.1(et Med)-500()-499.9(V)140.1(ol. 2, No)34.9(. 3, 2004)]TJ
ET
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1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
1 g
/GS1 gs
27 639 180 -594.002 re
f
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F1 1 Tf
10 0 0 10 28 300.1666 Tm
0 0 0 1 k
/GS1 gs
-0.0052 Tc
0 Tw
(trifug)Tj
0 g
2.1863 0 TD
0.025 Tw
(ation at 900 g for 10 minutes at 4C,)Tj
-2.1863 -1.2 TD
[(and used for measuring the acti)24.7(vities of)]TJ
T*
[(aspar)-19.9(tate aminotransferase \(AST\),)-270.2(alanine)]TJ
T*
[(aminotransferase \(AL)91.7(T\), alkaline phos-)]TJ
T*
[(phatase \(ALP\), and bilir)-19.9(ubin concentration)]TJ
T*
(using the Boehringer Mannheim/Hitachi)Tj
T*
0 Tw
[(autoanal)24.8(yzer)19.7(-902. )]TJ
1.5 -1.35 TD
0.025 Tw
[(Li)24.8(v)14.8(e)0.1(r mor)-29.9(pholo)24.8(gy w)24.8(as assessed b)24.8(y)-0.1( an)]TJ
-1.5 -1.2 TD
[(obser)-19.9(v)14.8(er b)19.7(linded to the treatments. Pieces of)]TJ
T*
[(the same lobe of li)24.8(v)14.8(er from each animal)]TJ
T*
0 Tc
0 Tw
(w)Tj
0.682 0 TD
-0.0051 Tc
0.025 Tw
[(ere tak)9.7(en and dipped in for)-19.9(mol-saline. )49.7(The)]TJ
-0.682 -1.2 TD
0.0546 Tc
0 Tw
(fi)Tj
0.6604 0 TD
(x)Tj
0.4652 0 TD
-0.0051 Tc
0.025 Tw
[(ed tissue w)24.8(as cut into 5-m sections,)]TJ
-1.1256 -1.2 TD
[(processed)59.7(, and stained with hemato)19.6(xylin and)]TJ
T*
[(eosin. Li)24.8(v)14.8(er sections w)34.8(ere anal)24.8(yzed b)24.8(y)-0.1( an)]TJ
T*
0 Tc
0 Tw
(e)Tj
0.424 0 TD
-0.0051 Tc
0.025 Tw
[(xaminer b)19.7(linded to the treatments. )]TJ
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F4 1 Tf
10 0 0 10 28 113.6666 Tm
0 0 0 1 k
/GS1 gs
-0.0001 Tc
0 Tw
(Statistical )Tj
0 g
4.4105 0 TD
[(Anal)19.7(ysis )]TJ
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F1 1 Tf
10 0 0 10 28 99.6665 Tm
0 0 0 1 k
/GS1 gs
0 Tc
0 Tw
(V)Tj
0 g
0.6011 0 TD
-0.0101 Tc
0.025 Tw
[(alues repor)-19.8(ted are means )-265.1(SE \(n = 10\).)]TJ
-0.6011 -1.2 TD
[(Experimental results w)34.9(e)0.1(re statisticall)24.9(y)0( ana-)]TJ
T*
0 Tc
0 Tw
(l)Tj
0.2429 0 TD
-0.0101 Tc
0.025 Tw
[(yzed using the Student)139.9(s )]TJ
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F3 1 Tf
10 0 0 10 128.0641 75.6665 Tm
0 0 0 1 k
/GS1 gs
0 Tc
0 Tw
(t)Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F1 1 Tf
10 0 0 10 130.7425 75.6665 Tm
0 0 0 1 k
/GS1 gs
-0.0101 Tc
0.025 Tw
(-test for unpaired)Tj
0 g
-10.2742 -1.2 TD
(data, with )Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F3 1 Tf
10 0 0 10 69.3318 63.6665 Tm
0 0 0 1 k
/GS1 gs
0 Tc
0 Tw
(P)Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F1 1 Tf
10 0 0 10 77.9903 63.6665 Tm
0 0 0 1 k
/GS1 gs
0 Tc
0 Tw
(v)Tj
0 g
0.4651 0 TD
-0.0101 Tc
0.025 Tw
(alue of less than .05 consider-)Tj
-5.4641 -1.2 TD
[(ed signif)-59.9(icant.)]TJ
ET
1 g
225 639 180 -594.002 re
f
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F2 1 Tf
10 0 0 10 226 299.7051 Tm
0 0 0 1 k
/GS1 gs
-0.0001 Tc
0 Tw
(RESUL)Tj
0 g
2.8926 0 TD
-0.0002 Tc
(TS)Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F1 1 Tf
10 0 0 10 226 285.5051 Tm
0 0 0 1 k
/GS1 gs
-0.0101 Tc
0.025 Tw
(The CCl)Tj
6 0 0 6 259.7154 283.5251 Tm
0 g
0 Tc
0 Tw
(4)Tj
10 0 0 10 262.6555 285.5051 Tm
-0.0101 Tc
0.025 Tw
[(-treated animals e)14.9(xhibited a signif)-59.8(i-)]TJ
-3.6655 -1.22 TD
(cant increase \()Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F3 1 Tf
10 0 0 10 282.7328 273.3051 Tm
0 0 0 1 k
/GS1 gs
0 Tc
0 Tw
(P)Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F1 1 Tf
10 0 0 10 288.7412 273.3051 Tm
0 0 0 1 k
/GS1 gs
-0.0101 Tc
0.025 Tw
(<.01\) in plasma enzyme)Tj
0 g
-6.2741 -1.22 TD
[(acti)24.8(vity and bilir)-19.8(ubin concentration com-)]TJ
T*
[(pared with saline-treated control rats \(T)79.9(ab)19.7(le)]TJ
T*
[(1\). )54.8(A signif)-59.9(icant reduction w)24.9(as found in ele-)]TJ
T*
0 Tc
0 Tw
(v)Tj
0.4651 0 TD
-0.0101 Tc
0.025 Tw
[(ated )54.9(AST)99.8(, )54.8(AL)91.7(T)99.9(,)-0.1( and )54.9(ALP v)24.8(alues in rats sub-)]TJ
-0.4651 -1.22 TD
(jected to both pre- and post-treatments with)Tj
T*
[(the aqueous e)14.9(xtracts of both date flesh and)]TJ
T*
[(date pits. Li)24.9(v)14.8(er enzyme v)24.9(alues w)34.9(ere higher)]TJ
T*
[(in the four e)14.9(xperimental g)-19.8(roups than in the)]TJ
T*
[(saline-treated controls, but the li)24.9(v)14.9(er enzyme)]TJ
T*
0 Tc
0 Tw
(v)Tj
0.4651 0 TD
-0.0101 Tc
0.025 Tw
[(alues w)34.9(ere decreased to about half of those)]TJ
-0.4651 -1.22 TD
(found in CCl)Tj
6 0 0 6 277.5248 137.1252 Tm
0 Tc
0 Tw
(4)Tj
10 0 0 10 280.4648 139.1052 Tm
-0.0101 Tc
0.025 Tw
(-treated control animals for all)Tj
-5.4465 -1.22 TD
[(li)24.8(v)14.8(er function tests e)14.9(xcept bilir)-19.8(ubin. )]TJ
1.5 -1.37 TD
-0.0051 Tc
(Expressed in percentage of protection)Tj
-1.5 -1.22 TD
[(pro)44.8(vided)59.7(, both date palm flesh and pits)]TJ
T*
[(gi)24.8(v)14.8(en pre- or post-treatment w)34.8(ere hepatopro-)]TJ
T*
[(tecti)24.8(v)14.8(e, as calculated b)24.8(y)0( the for)-19.9(mula of)]TJ
T*
(Singh et al.)Tj
5 0 0 5 271.1714 67.874 Tm
0 Tc
0 Tw
(7)Tj
10 0 0 10 275.8484 64.4053 Tm
-0.085 Tc
(Ta)Tj
0.9649 0 TD
(b)Tj
0.4752 0 TD
-0.0051 Tc
0.025 Tw
(le 2 presents the results of)Tj
-6.4249 -1.22 TD
(our calculations of hepatoprotection as pro-)Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F9 1 Tf
8 0 0 8 34 632.0801 Tm
0 0 0 1 k
/GS1 gs
0 Tc
0 Tw
(T)Tj
0 g
0.3501 0 TD
0.0005 Tc
0.0273 Tw
(able 1.)Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F10 1 Tf
8 0 0 8 68.1422 632.0801 Tm
0 0 0 1 k
/GS1 gs
-0.0001 Tc
0 Tw
(Ef)Tj
0 g
0.7901 0 TD
0 Tc
(f)Tj
0.2942 0 TD
-0.0002 Tc
0.0277 Tw
[(ect of Pre- and P)59.6(ost-treatment with )19.6(Aqueous Date Flesh and Pits on CCl)]TJ
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F1 1 Tf
6 0 0 6 355.3842 630.1002 Tm
0 0 0 1 k
/GS1 gs
0 Tc
0 Tw
(4)Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F10 1 Tf
8 0 0 8 360.7905 632.0801 Tm
0 0 0 1 k
/GS1 gs
-0.0002 Tc
0 Tw
(-Induced)Tj
0 g
-40.8488 -1.125 TD
-0.0001 Tc
0.0276 Tw
[(Liv)19.7(er Dam)19.7(age in )24.7(W)-5.9(istar Rats)]TJ
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F11 1 Tf
8 0 0 8 146.5566 613.0802 Tm
0 0 0 1 k
/GS1 gs
-0.0001 Tc
0 Tw
(Aspartate)Tj
0 g
9.6249 0 TD
-0.0002 Tc
(Alanine)Tj
-11.4865 -1.25 TD
-0.0001 Tc
[(aminotransferase)-791.1(aminotransferase)-2791.1(Alkaline)-3680.7(Bilirubin)]TJ
-12.208 -1.25 TD
0 Tc
(T)Tj
0.5559 0 TD
-0.0002 Tc
0.0278 Tw
[(reatment)-10459.3(\(U/L\))-6849.1(\(U/L\))-3237.9(phosphastase \(U/L\))-849(\(mol/L\))]TJ
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F12 1 Tf
8 0 0 8 34 577.0801 Tm
0 0 0 1 k
/GS1 gs
-0.0001 Tc
0 Tw
(Control)Tj
0 g
13.5539 0 TD
0.0279 Tw
[(106.8 )-305.7(3.29)-3482.9(34.62 )-305.7(1.34)-3232.9(155.0 )-305.7(2.54)-2260.8(0.17 )-305.7(0.03)]TJ
-13.5539 -1.625 TD
[(Date flesh pre-treatment)-2719.6(136.6 )-305.7(3.12)-3604.6(46.6 )-305.7(1.77)]TJ
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F1 1 Tf
5 0 0 5 257.0953 567.5488 Tm
0 0 0 1 k
/GS1 gs
0 Tc
0 Tw
()Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F12 1 Tf
8 0 0 8 285.181 564.0801 Tm
0 0 0 1 k
/GS1 gs
-0.0001 Tc
0 Tw
(180.4 )Tj
0 g
2.8071 0 TD
0 Tc
()Tj
0.8896 0 TD
-0.0001 Tc
(1.97)Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F1 1 Tf
5 0 0 5 330.319 567.5488 Tm
0 0 0 1 k
/GS1 gs
0 Tc
0 Tw
()Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F12 1 Tf
8 0 0 8 349.6547 564.0801 Tm
0 0 0 1 k
/GS1 gs
-0.0002 Tc
0 Tw
(0.19 )Tj
0 g
2.2512 0 TD
0 Tc
()Tj
0.8896 0 TD
-0.0001 Tc
(0.01)Tj
-42.5976 -1.625 TD
0.0278 Tw
[(Date flesh post-treatment)-2118.3(124.4 )-305.7(4.27)]TJ
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F1 1 Tf
5 0 0 5 186.319 554.5488 Tm
0 0 0 1 k
/GS1 gs
0 Tc
0 Tw
()Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F12 1 Tf
8 0 0 8 214.181 551.0801 Tm
0 0 0 1 k
/GS1 gs
-0.0001 Tc
0 Tw
(43.68 )Tj
0 g
2.8071 0 TD
0 Tc
()Tj
0.8896 0 TD
-0.0001 Tc
(0.64)Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F1 1 Tf
5 0 0 5 259.319 554.5488 Tm
0 0 0 1 k
/GS1 gs
0 Tc
0 Tw
()Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F12 1 Tf
8 0 0 8 285.181 551.0801 Tm
0 0 0 1 k
/GS1 gs
-0.0001 Tc
0 Tw
(192.4 )Tj
0 g
2.8071 0 TD
0 Tc
()Tj
0.8896 0 TD
-0.0001 Tc
(4.72)Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F1 1 Tf
5 0 0 5 330.319 554.5488 Tm
0 0 0 1 k
/GS1 gs
0 Tc
0 Tw
()Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F12 1 Tf
8 0 0 8 349.6547 551.0801 Tm
0 0 0 1 k
/GS1 gs
-0.0002 Tc
0 Tw
(0.20 )Tj
0 g
2.2512 0 TD
0 Tc
()Tj
0.8896 0 TD
-0.0001 Tc
(0.01)Tj
-42.5976 -1.625 TD
0.0277 Tw
[(Date pits pre-treatment)-3119.2(162.0 )-305.7(4.64)]TJ
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F1 1 Tf
5 0 0 5 186.319 541.5488 Tm
0 0 0 1 k
/GS1 gs
0 Tc
0 Tw
()Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F12 1 Tf
8 0 0 8 214.181 538.0801 Tm
0 0 0 1 k
/GS1 gs
-0.0001 Tc
0 Tw
(59.80 )Tj
0 g
2.8071 0 TD
0 Tc
()Tj
0.8896 0 TD
-0.0001 Tc
(1.58)Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F1 1 Tf
5 0 0 5 259.319 541.5488 Tm
0 0 0 1 k
/GS1 gs
0 Tc
0 Tw
()Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F12 1 Tf
8 0 0 8 285.181 538.0801 Tm
0 0 0 1 k
/GS1 gs
-0.0001 Tc
0 Tw
(181.4 )Tj
0 g
2.8071 0 TD
0 Tc
()Tj
0.8896 0 TD
-0.0001 Tc
(3.17)Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F1 1 Tf
5 0 0 5 330.319 541.5488 Tm
0 0 0 1 k
/GS1 gs
0 Tc
0 Tw
()Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F12 1 Tf
8 0 0 8 349.6547 538.0801 Tm
0 0 0 1 k
/GS1 gs
-0.0002 Tc
0 Tw
(0.21 )Tj
0 g
2.2512 0 TD
0 Tc
()Tj
0.8896 0 TD
-0.0001 Tc
(0.01)Tj
-42.5976 -1.625 TD
0.0278 Tw
[(Date pits post-treatment)-2674.2(158.4 )-305.7(6.43)]TJ
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F1 1 Tf
5 0 0 5 186.319 528.5488 Tm
0 0 0 1 k
/GS1 gs
0 Tc
0 Tw
()Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F12 1 Tf
8 0 0 8 214.181 525.0801 Tm
0 0 0 1 k
/GS1 gs
-0.0001 Tc
0 Tw
(57.40 )Tj
0 g
2.8071 0 TD
0 Tc
()Tj
0.8896 0 TD
-0.0001 Tc
(1.34)Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F1 1 Tf
5 0 0 5 259.319 528.5488 Tm
0 0 0 1 k
/GS1 gs
0 Tc
0 Tw
()Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F12 1 Tf
8 0 0 8 284.2074 525.0801 Tm
0 0 0 1 k
/GS1 gs
-0.0001 Tc
0 Tw
(172.2 )Tj
0 g
2.8071 0 TD
0 Tc
()Tj
0.8896 0 TD
-0.0001 Tc
0.0279 Tw
[(10.33)-1982.9(0.20 )-305.7(0.00)]TJ
-34.9726 -1.625 TD
[(Carbon tetrachloride)-4313.3(282.6 )-305.7(2.96)]TJ
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F1 1 Tf
5 0 0 5 186.319 515.5488 Tm
0 0 0 1 k
/GS1 gs
0 Tc
0 Tw
()Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F12 1 Tf
8 0 0 8 216.4047 512.0801 Tm
0 0 0 1 k
/GS1 gs
-0.0002 Tc
0 Tw
(85.6 )Tj
0 g
2.2512 0 TD
0 Tc
()Tj
0.8896 0 TD
-0.0001 Tc
(1.99)Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F1 1 Tf
5 0 0 5 257.0953 515.5488 Tm
0 0 0 1 k
/GS1 gs
0 Tc
0 Tw
()Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F12 1 Tf
8 0 0 8 285.181 512.0801 Tm
0 0 0 1 k
/GS1 gs
-0.0001 Tc
0 Tw
(253.4 )Tj
0 g
2.8071 0 TD
0 Tc
()Tj
0.8896 0 TD
-0.0001 Tc
(5.44)Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F1 1 Tf
5 0 0 5 330.319 515.5488 Tm
0 0 0 1 k
/GS1 gs
0 Tc
0 Tw
()Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F12 1 Tf
8 0 0 8 348.4047 512.0801 Tm
0 0 0 1 k
/GS1 gs
-0.0002 Tc
0 Tw
(3.29 )Tj
0 g
2.2512 0 TD
0.3056 Tc
(0)Tj
1.4454 0 TD
-0.0001 Tc
(.06)Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F1 1 Tf
5 0 0 5 389.0953 515.5488 Tm
0 0 0 1 k
/GS1 gs
0 Tc
0 Tw
()Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F12 1 Tf
7 0 0 7 34 499.0801 Tm
0 0 0 1 k
/GS1 gs
-0.0001 Tc
0.0278 Tw
(Data are expressed as mean )Tj
0 g
13.2529 0 TD
0 Tc
0 Tw
()Tj
0.8896 0 TD
-0.0001 Tc
0.0278 Tw
(SE \(n = 10\))Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F1 1 Tf
5 0 0 5 34 493.5488 Tm
0 0 0 1 k
/GS1 gs
0 Tc
0 Tw
()Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F12 1 Tf
7 0 0 7 36.475 490.0801 Tm
0 0 0 1 k
/GS1 gs
-0.0001 Tc
0.0278 Tw
(Significantly dif)Tj
0 g
6.6774 0 TD
(ferent than control at )Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F13 1 Tf
7 0 0 7 150.1242 490.0801 Tm
0 0 0 1 k
/GS1 gs
0 Tc
0 Tw
(P)Tj
0 g
0.9548 0 TD
(<)Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F12 1 Tf
7 0 0 7 163.0349 490.0801 Tm
0 0 0 1 k
/GS1 gs
-0.0002 Tc
0 Tw
(.01.)Tj
ET
0 G
0 J 0 j 1 w 10 M []0 d
27.5 620.5 377 -112.501 re
174.706 490.08 m
27 588.5 m
405 588.5 l
S
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F9 1 Tf
8 0 0 8 34 463.9761 Tm
0 0 0 1 k
/GS1 gs
0 Tc
0 Tw
(T)Tj
0 g
0.3501 0 TD
0.0005 Tc
0.0273 Tw
(able 2.)Tj
ET
Q
q
1 i
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(Hepatopr)Tj
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[(otectiv)19.7(e )19.7(Activity of Date Flesh and Pits in CCl)]TJ
ET
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(4)Tj
ET
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(-Induced Hepatoto)Tj
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9.4164 0 TD
-0.0001 Tc
(xicity in)Tj
-40.2347 -1.125 TD
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(W)Tj
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-0.0001 Tc
0.0277 Tw
(istar Rats)Tj
ET
Q
q
1 i
-9 675 459 -684 re
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W n
0.06 666.06 441 -666 re
W n
BT
/F11 1 Tf
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/GS1 gs
-0.0001 Tc
0.0278 Tw
(Clinical Chemistry)Tj
0 g
17.7507 0 TD
[(Date Flesh)-12889(Date Pits)]TJ
-17.7507 -1.125 TD
-0.0002 Tc
[(Liver Function)-6459.8(Pre-treatment)-1411.1(Post-treatment)-2161.1(Pre-treatment)-1695.8(Post- treatment)]TJ
T*
[(Indicator)-9029.8(\(% protection\))-1440.2(\(% protection\) )-1884.5(\(% protection\))-1877.7(\(% protection\))]TJ
ET
Q
q
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W n
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W n
BT
/F12 1 Tf
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0.0278 Tw
(Aspartate aminotransferase)Tj
0 g
15.3743 0 TD
0 Tw
[(83.05)-5686.1(89.99)-6436.1(68.60)-6123.6(70.65)]TJ
-15.3743 -1.625 TD
0.0278 Tw
[(Alanine aminotransferase)-4011.1(76.50)-5686.1(82.23)-6436.1(50.61)-6123.6(55.32)]TJ
T*
[(Alkaline phosphatase)-5843.2(74.19)-5686.1(61.99)-6436.1(73.17)-6123.6(82.52)]TJ
T*
0 Tw
[(Bilirubin)-11819.2(99.36)-5686.1(99.04)-6436.1(96.00)-6123.6(99.04)]TJ
7 0 0 7 34 351.9761 Tm
0.0278 Tw
(% Protection = 1 )Tj
8.9194 0.5714 TD
-0.0002 Tc
(\(PC - S\) )Tj
3.9711 -0.5714 TD
-0.0001 Tc
(x 100)Tj
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-0.0002 Tc
(\(C - S\))Tj
-9.1685 -1.2857 TD
-0.0001 Tc
(where PC, C, and S are the measurable variables in rats treated with date flesh or pits plus CCl)Tj
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/GS1 gs
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(4)Tj
ET
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W n
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(, CCl)Tj
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(4,)Tj
ET
Q
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W n
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/F12 1 Tf
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/GS1 gs
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0.0278 Tw
(and saline-)Tj
0 g
-46.2305 -1.2857 TD
[(treated animals, respectively)73.9(.)]TJ
ET
0 G
0 J 0 j 1 w 10 M []0 d
27.5 452.396 377 -87.501 re
124.493 328.976 m
27 420.396 m
405 420.396 l
S
0.5 w
95.5 353.5 m
122 353.5 l
S
Q
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/F3 1 Tf
9.5 0 0 9.5 221.1381 26.7502 Tm
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/GS1 gs
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0 Tw
(V)Tj
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0.4709 0 TD
-0.0001 Tc
0.025 Tw
[(ol. 2, No)34.8(. 3, 2004 )-500.1(Intern J )59.7(Appl Res )74.9(V)140(et Med)]TJ
ET
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f
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(vided b)Tj
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(y date palm flesh and pits in CCl)Tj
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0 Tw
(4)Tj
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(-)Tj
-16.3804 -1.22 TD
-0.0051 Tc
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[(induced to)19.7(xicity in rats.)]TJ
ET
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(DISCUSSION)Tj
ET
Q
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(Li)Tj
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0.8538 0 TD
0 Tc
(v)Tj
0.4801 0 TD
-0.0051 Tc
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[(er cir)-29.9(rhosis induced b)24.8(y)-0.1( CCl)]TJ
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0 Tc
0 Tw
(4)Tj
10 0 0 10 165.6768 580.8616 Tm
-0.0051 Tc
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(is perhaps)Tj
-12.8677 -1.2 TD
[(the best-studied model of li)24.7(v)14.8(er cir)-29.9(rhosis.)]TJ
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0 Tc
0 Tw
(8)Tj
10 0 0 10 37 556.8616 Tm
-0.0051 Tc
0.025 Tw
[(Se)24.8(v)14.8(eral mechanisms underl)24.8(ying this to)19.7(xicity)]TJ
T*
[(ha)34.8(v)14.8(e)0( been suggested.)]TJ
5 0 0 5 120.69 548.3303 Tm
0 Tc
0 Tw
(9)Tj
10 0 0 10 125.367 544.8616 Tm
-0.0051 Tc
0.025 Tw
(The reduction of)Tj
-8.8367 -1.2 TD
0 Tw
(CCl)Tj
6 0 0 6 52.9682 530.8815 Tm
0 Tc
(4)Tj
10 0 0 10 55.9383 532.8615 Tm
-0.0051 Tc
0.025 Tw
[(-induced ele)24.8(v)24.8(ated plasma acti)24.8(vities of)]TJ
-1.8938 -1.2 TD
[(AST)99.8(,)-0.1( )54.8(AL)91.7(T)99.9(,)-0.1( )54.8(ALP)159.8(,)0( and bilir)-19.9(ubin le)24.8(v)14.8(el in ani-)]TJ
T*
(mals pre- and post-treated with the aqueous)Tj
T*
0 Tc
0 Tw
(e)Tj
0.424 0 TD
-0.0051 Tc
0.025 Tw
[(xtracts of date flesh or pits sho)39.6(ws their)]TJ
-0.424 -1.2 TD
[(ability to restore the nor)-19.9(mal functional sta-)]TJ
T*
[(tus of the poisoned li)24.8(v)14.8(e)0.3(r)39.7(,)0( and also to protect)]TJ
T*
-0.0053 Tc
0.0252 Tw
(against subsequent CCl)Tj
6 0 0 6 130.2263 458.8815 Tm
0 Tc
0 Tw
(4)Tj
10 0 0 10 135.8964 460.8615 Tm
-0.0051 Tc
[(hepatoto)19.7(xicity)84.9(. )]TJ
-8.3896 -1.35 TD
0.025 Tw
[(The mechanism b)24.8(y)-0.1( w)19.7(hich the date pits)]TJ
-1.5 -1.2 TD
[(and flesh)-270.1(induces its hepatoprotecti)24.8(v)14.8(e)0.1( acti)24.8(v)0.1(i-)]TJ
T*
[(ty is not cer)-19.9(tain. Ho)39.7(w)34.9(e)25(v)14.8(e)0.3(r)39.7(,)0( it is possib)19.7(le that)]TJ
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F8 1 Tf
10 0 0 10 37 411.3615 Tm
0 0 0 1 k
/GS1 gs
0 Tc
0 Tw
()Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F1 1 Tf
10 0 0 10 42.4383 411.3615 Tm
0 0 0 1 k
/GS1 gs
-0.0051 Tc
0.025 Tw
(-sitosterol, a constituent of )Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F3 1 Tf
10 0 0 10 151.07 411.3615 Tm
0 0 0 1 k
/GS1 gs
-0.0051 Tc
0 Tw
(Phoenix)Tj
0 g
-11.407 -1.2 TD
[(dactylif)19.7(er)44.8(a)]TJ
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F1 1 Tf
10 0 0 10 79.1212 399.3616 Tm
0 0 0 1 k
/GS1 gs
0 Tc
0 Tw
(,)Tj
5 0 0 5 81.5712 402.8303 Tm
0 g
(1)Tj
10 0 0 10 86.7463 399.3616 Tm
-0.0051 Tc
0.025 Tw
[(is at least par)-19.9(tl)24.8(y responsib)19.7(le for)]TJ
-4.9746 -1.2 TD
-0.0053 Tc
0.0252 Tw
[(the protecti)24.6(v)14.6(e)-0.1( acti)24.6(vity against CCl)]TJ
6 0 0 6 172.1812 385.3816 Tm
0 Tc
0 Tw
(4)Tj
10 0 0 10 177.8513 387.3615 Tm
-0.0051 Tc
(hepato-)Tj
-14.0851 -1.2 TD
[(to)19.7(xicity)84.9(.)]TJ
5 0 0 5 68.5546 378.8303 Tm
(10)Tj
10 0 0 10 76.2047 375.3615 Tm
(CCl)Tj
6 0 0 6 92.1729 373.3816 Tm
0 Tc
(4)Tj
10 0 0 10 95.143 375.3615 Tm
-0.0051 Tc
0.025 Tw
[(, the inacti)24.8(v)14.8(e)0( metabolite, is)]TJ
-5.8143 -1.2 TD
[(transfor)-19.9(med to a free radical through the)]TJ
T*
[(microsomal c)14.8(ytochrome P-450-dependent)]TJ
T*
[(enzyme, resulting in acti)24.7(v)24.8(ation of CCl)]TJ
6 0 0 6 188.5899 337.3816 Tm
0 Tc
0 Tw
(4)Tj
10 0 0 10 194.2599 339.3615 Tm
-0.0051 Tc
[(to)19.7(xi-)]TJ
-15.726 -1.2 TD
0.025 Tw
[(city)84.9(.)-0.1( )54.8(An additional and impor)-19.9(tant f)-9.9(actor in)]TJ
T*
[(the hepatoprotecti)24.8(v)14.8(e)0.1( acti)24.8(vity of an)24.8(y dr)-19.9(ug is)]TJ
T*
(the ability of its constituents to inhibit the)Tj
T*
[(aromatase acti)24.8(vity of c)14.8(ytochrome P-450,)]TJ
T*
[(thereb)24.8(y f)-9.9(a)35(v)19.7(oring li)24.8(v)14.8(er re)14.8(generation. On that)]TJ
T*
[(basis, it is suggested that fla)34.7(v)19.7(onoids in)]TJ
ET
Q
q
1 i
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0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F3 1 Tf
10 0 0 10 37 255.3615 Tm
0 0 0 1 k
/GS1 gs
-0.0051 Tc
0.025 Tw
(Phoenix dactylif)Tj
0 g
6.4507 0 TD
0 Tw
[(er)44.7(a)]TJ
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F1 1 Tf
10 0 0 10 116.9351 255.3615 Tm
0 0 0 1 k
/GS1 gs
-0.0051 Tc
0.025 Tw
(could be a f)Tj
0 g
4.7169 0 TD
(actor con-)Tj
-12.7105 -1.2 TD
-0.005 Tc
[(tributing to its hepatoprotecti)24.8(v)14.9(e)0.1( ability)]TJ
T*
-0.0051 Tc
[(through inhibition of c)14.8(ytochrome P-450 aro-)]TJ
T*
0 Tw
(matase.)Tj
5 0 0 5 66.9114 222.8303 Tm
(11)Tj
10 0 0 10 74.5615 219.3615 Tm
0.025 Tw
(In addition, the recorded content)Tj
-3.7562 -1.2 TD
(of vitamin C in the date flesh and pits)Tj
T*
[(\(0.179% and 0.137%, respecti)24.7(v)14.8(e)0.2(l)24.8(y\) ma)34.8(y also)]TJ
T*
[(pla)34.8(y)0( a role in hepatoprotection. Pre)24.7(vious in)]TJ
T*
[(vi)24.8(v)19.7(o)0( studies indicate that hepatic microso-)]TJ
T*
[(mal dr)-19.9(ug metabolism decreases in ascorbic)]TJ
T*
[(acid def)-59.9(icienc)14.8(y and is augmented w)19.7(hen high)]TJ
T*
[(supplements of the vitamin are gi)24.7(v)14.8(en to)]TJ
T*
(guinea pigs.)Tj
5 0 0 5 84.9731 126.8304 Tm
-0.005 Tc
0 Tw
(12,13 )Tj
10 0 0 10 97.4481 123.3615 Tm
-0.0051 Tc
0.0249 Tw
[(Li)24.8(v)14.8(er c)14.8(ytochrome P-450 is)]TJ
-6.0448 -1.2 TD
[(signif)-59.9(icantl)24.8(y reduced in ascorbic acid-def)-60(i-)]TJ
T*
(cient guinea pigs.)Tj
5 0 0 5 106.8569 102.8304 Tm
0 Tw
(14)Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F2 1 Tf
10 0 0 10 37 76.3616 Tm
0 0 0 1 k
/GS1 gs
-0.0001 Tc
0 Tw
(CONCLUSIONS)Tj
ET
Q
q
1 i
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0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F1 1 Tf
10 0 0 10 37 62.3616 Tm
0 0 0 1 k
/GS1 gs
-0.0051 Tc
0.025 Tw
(This study clearl)Tj
0 g
6.6045 0 TD
[(y demonstrates that e)14.7(x)0.1(tracts)]TJ
-6.6045 -1.2 TD
[(of date flesh and date pits are ef)24.7(fecti)24.8(v)14.8(e)]TJ
ET
1 g
234 639 180 -594.002 re
f
BT
10 0 0 10 235 631.0615 Tm
0 g
[(agents in the treatment and pre)24.7(v)14.8(ention of)]TJ
T*
0 Tw
(CCl)Tj
6 0 0 6 250.9682 617.0815 Tm
0 Tc
(4)Tj
10 0 0 10 253.9383 619.0615 Tm
-0.0051 Tc
0.025 Tw
[(-induced hepatic c)14.8(ytoto)19.7(xicity)84.9(. )49.7(The data)]TJ
-1.8938 -1.2 TD
[(suggest that the dail)24.8(y oral consumption of)]TJ
T*
[(an aqueous e)14.8(xtract of the flesh and pits of)]TJ
T*
[(dates, and as a par)-19.9(t of the dail)24.8(y diet ad libi-)]TJ
T*
[(tum, w)24.8(as proph)29.7(ylactic to CCl)]TJ
6 0 0 6 351.532 569.0815 Tm
0 Tc
0 Tw
(4)Tj
10 0 0 10 357.202 571.0615 Tm
-0.005 Tc
(poisoning,)Tj
-12.2202 -1.2 TD
-0.0051 Tc
0.025 Tw
[(achie)24.8(ving about 80% protection with date)]TJ
T*
[(palm flesh and 70% with pits. )54.8(A similar per-)]TJ
T*
[(centage of protection w)24.8(as achie)24.8(v)14.8(ed w)19.7(hen the)]TJ
T*
[(aqueous e)14.8(xtracts of the flesh and pits w)34.8(ere)]TJ
T*
-0.0053 Tc
0.0252 Tw
(used as a cure against CCl)Tj
6 0 0 6 340.1412 509.0815 Tm
0 Tc
0 Tw
(4)Tj
10 0 0 10 345.8113 511.0615 Tm
-0.0051 Tc
0.025 Tw
(poisoning after)Tj
-11.0811 -1.2 TD
[(to)19.7(xicity w)24.8(as induced. )]TJ
1.5 -1.36 TD
[(Of g)-19.8(reater impor)-19.9(tance to the pub)19.7(lic is)]TJ
-1.5 -1.21 TD
[(the ef)24.8(fect of ingesting nor)-19.9(mal ad libitum)]TJ
T*
[(le)24.8(v)14.8(els of date palm \(flesh or/and pits\), par-)]TJ
T*
[(ticularl)24.8(y because it is an ine)14.8(xpensi)24.8(v)14.8(e)0( and)]TJ
T*
[(ef)24.8(fecti)24.8(v)14.8(e)0( proph)29.7(ylactic and/or treatment)]TJ
T*
[(against li)24.7(v)14.7(er c)14.7(ytoto)19.6(xicity and a dynamic)]TJ
T*
[(li)24.8(v)14.8(er suppor)-19.9(t. )49.7(This study)84.9(, along with other)]TJ
T*
[(research, tar)17.7(gets )]TJ
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F3 1 Tf
10 0 0 10 301.871 400.7617 Tm
0 0 0 1 k
/GS1 gs
-0.0051 Tc
0.025 Tw
(Phoenix dactylif)Tj
0 g
6.4507 0 TD
0 Tw
[(er)44.7(a)]TJ
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F1 1 Tf
10 0 0 10 381.8062 400.7617 Tm
0 0 0 1 k
/GS1 gs
-0.0051 Tc
0.025 Tw
(L. as a)Tj
0 g
-14.6806 -1.21 TD
[(potentiall)24.8(y safe and ef)24.8(fecti)24.8(v)14.8(e)0( plant that has)]TJ
T*
[(impor)-19.9(tant medicinal v)24.8(alues and benef)-59.9(its. )]TJ
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F4 1 Tf
10 0 0 10 235 359.5616 Tm
0 0 0 1 k
/GS1 gs
-0.0001 Tc
0 Tw
(Ackno)Tj
0 g
2.7278 0 TD
(wledgments)Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F1 1 Tf
10 0 0 10 235 345.4617 Tm
0 0 0 1 k
/GS1 gs
-0.0051 Tc
0.025 Tw
(The authors w)Tj
0 g
5.6652 0 TD
[(ould lik)9.7(e to thank Professor S.)]TJ
-5.6652 -1.21 TD
[(Al-Y)139.8(ah)29.7(ya, Dean of the Colle)14.8(ge of )54.8(Ag)-19.9(ri-)]TJ
T*
[(culture and )49.7(V)110.8(eterinar)-19.9(y Medicine at King)]TJ
T*
[(Saud Uni)24.8(v)14.8(ersity)-270.1(for his interest and suppor)-19.9(t)]TJ
T*
(of this research. )Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F2 1 Tf
10 0 0 10 235 273.0618 Tm
0 0 0 1 k
/GS1 gs
-0.0002 Tc
0 Tw
(REFERENCES)Tj
ET
Q
q
1 i
-9 675 459 -684 re
0 666 m
W n
0.06 666.06 441 -666 re
W n
BT
/F1 1 Tf
8 0 0 8 243 258.9618 Tm
0 0 0 1 k
/GS1 gs
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